It's simply too difficult to choose just one song from Madvillainy, an album full of "10 out of 10's" that ultimately all sound very similar, and work best within the context of the LP. Where to turn? There's "Figaro" (with MF Doom's strongest and most memorable lyrics to date) and "All Caps" (with a classic once-sung refrain). We strongly considered the unheralded tripped-out jazz-funk surge "Shadows of Tomorrow," with Quasimoto interpreting Sun Ra.
We ultimately decided to run with P4k's choice. ("America's Most Blunted" has an entry in the book The Pitchfork 500 and also placed on their 500 best 2000's jams). It doesn't necessarily tower over everything else on Madvillainy, but its warpy disjointed production (filled with 10 or 12 samples not unlike the sprawl throughout Paul's Boutique) best encapsulates the essence of Madvillain, who wisely chose not to release any other LP's. Their legend is best left untainted by a follow-up.